Pharmacological properties Azelex Cream:
Azelex The therapeutic efficacy in the treatment of acne makes its antimicrobial action and a direct influence on follicular hyperkeratosis.
Clinically significant reduction of the density of colonization Propionibacterium acnes and a significant decrease in fraction of free fatty acids in the lipids of the skin surface.
Azelaic acid in vitro and in vivo inhibits the proliferation of keratinocytes and normalizes the process of terminal differentiation of violation of the epidermis during the formation of acne. In the model of the rabbit ear azelaic acid accelerates tetradecane-induced comedones komedolizis (blackheads).
Experimental results show that azelaic acid has an inhibitory effect depending on dose and duration of treatment on growth and viability of abnormal melanocytes.
The molecular mechanisms by which this process occurs is unclear. On the basis of available data’ve assumed that the main effects of azelaic acid in the treatment of melasma are due to inhibition of DNA synthesis and / or inhibition of cellular respiration is abnormal melanocytes.
After applying the funds to the skin surface, azelaic acid penetrates into all layers. The passage occurs at a faster rate through the affected skin than through intact. After a single application to the skin surface of 1 g azelaic acid n / a 3.6% absorbed dose applied.
Part of azelaic acid, absorbed through skin, excreted in the urine in unchanged form part of the exposed β-oxidation, becoming a dicarboxylic acid with at least a short chain length (C7, C5), which also detected in the urine.
Indications Azelex Cream:
acne treatment (conventional acne) and melasma.
Application Azelex Cream:
External, 2 times a day. The course of treatment – 2-6 months.
Contraindications Azelex Cream:
Hypersensitivity to azelaic acid.
Side effects Azelex Cream:
early in therapy may experience the phenomenon of local skin irritation (mainly itching or burning, sometimes – redness and peeling of the skin).
Cautions:
Avoid contact with eyes.
Azelaic acid
Azelaic acid (heptane-1 ,7-dicarboxylic acid, azelaic acid) – a popular ingredient in pharmaceutical drugs for the correction of acne (acne). Azelaic acid is formed during lipid metabolism and in small quantities contained in the human body. For pharmaceutical and cosmetic purposes azelaic acid are biochemically.
Azelaic acid has several effects. It is shown that it stops the growth of bacteria (Propionibacterium acnes and Staphylococcus epidermidis), which play a key role in the development of acne. Within a few weeks of using creams with azelaic acid bacteria on the skin is greatly reduced. It is important that this is not produced strains resistant to azelaic acid. Therefore, it is effective with prolonged use and is not “addictive.”
In addition to the antibacterial action, azelaic acid prevents keratinization of the upper layer of the skin, thus preventing clogging of pores and the appearance of comedones (blackheads on the skin). In addition, under the action of azelaic acid slows down the formation of dark spots.
Recent scientific studies have shown the antioxidant activity of azelaic acid, which, coupled with other effects makes it an effective cosmetic ingredient (daily gel for oily problem skin series “The Fly”).
Use of pharmaceutical products with azelaic acid should pay attention to its concentration. The fact is that at high doses azelaic acid may cause a slight burning sensation, redness of the skin. Therefore, pharmaceutical ointment with azelaic acid is not recommended for use after deep peels, as well as alcoholic beverages, pepper food, after lengthy sun exposure or irritated skin. Usually used for therapeutic purposes is not more than 20% azelaic acid. It should be noted that such concentrations of azelaic acid has no side effects, non-toxic, and can be used for a long time. Creams and ointments with azelaic acid can be used during pregnancy. Breastfeeding regular use and dosage should be reduced.
